Severe Symptomatic Hyponatremia during Citalopram Therapy

Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an uncommon complication of treatment with the new class of antidepressant agents, the selective serotonin reuptake inhibitors (SSRIs). Most of the reported cases were associated with fluoxetine; onl...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of the medical sciences 2001-02, Vol.321 (2), p.159-160
Main Authors: Odeh, Majed, Oliven, Arie, Beny, Ahuva
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Citalopram
Citalopram - adverse effects
Depression - drug therapy
Drug toxicity and drugs side effects treatment
Female
Humans
Hyponatremia
Hyponatremia - etiology
Inappropriate ADH Syndrome - chemically induced
Inappropriate ADH Syndrome - complications
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Selective serotonin reuptake inhibitors
Serotonin Uptake Inhibitors - adverse effects
Sleep Stages
Syndrome of inappropriate secretion of antidiuretic hormone
Tropical medicine
Vomiting - etiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is an uncommon complication of treatment with the new class of antidepressant agents, the selective serotonin reuptake inhibitors (SSRIs). Most of the reported cases were associated with fluoxetine; only 2 have previously been described in association with citalopram. We describe an elderly woman who presented with severe symptomatic hyponatremia caused by the SIADH during therapy with citalopram. Because the use of SSRIs is becoming more popular among elderly depressed patients, the present case and the other 2 reported previously emphasize the need for greater awareness of the development of this serious and potentially fatal complication also in association with citalopram therapy and suggest that serum sodium levels should be monitored closely in elderly patients during treatment with citalopram.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200102000-00009