Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin

We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity react...

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Bibliographic Details
Published in:The American journal of the medical sciences 2003-01, Vol.325 (1), p.31-33
Main Author: Zaidi, Syed A.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Amoxicillin-Potassium Clavulanate Combination - adverse effects
Amoxicillin/ clavulanic acid
Aspartate Aminotransferases - blood
Biological and medical sciences
Chemical and Drug Induced Liver Injury - diagnosis
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - therapy
Ciprofloxacin
Ciprofloxacin - adverse effects
Drug toxicity and drugs side effects treatment
Hepatotoxicity
Humans
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
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Description
Summary:We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity reaction, which may be attributable to either or both of the antimicrobial agents used. This gradually resolved over a 4-week time period, with conservative management. A review of the relevant literature on drug-induced hepatotoxicity is also presented.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200301000-00006