Loading…
Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin
We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity react...
Saved in:
| Published in: | The American journal of the medical sciences 2003-01, Vol.325 (1), p.31-33 |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73 |
| container_end_page | 33 |
| container_issue | 1 |
| container_start_page | 31 |
| container_title | The American journal of the medical sciences |
| container_volume | 325 |
| creator | Zaidi, Syed A. |
| description | We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity reaction, which may be attributable to either or both of the antimicrobial agents used. This gradually resolved over a 4-week time period, with conservative management. A review of the relevant literature on drug-induced hepatotoxicity is also presented. |
| doi_str_mv | 10.1097/00000441-200301000-00006 |
| format | article |
| fullrecord | <record><control><sourceid>elsevier_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00000441_200301000_00006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002962915343391</els_id><sourcerecordid>S0002962915343391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73</originalsourceid><addsrcrecordid>eNqFkE9Pg0AQxTdGY2v1KxguHrH7D1iOSNRqmnjRM1mGIY6hQHZprd9eaqs9OpfJvPzeZOYxFgh-K3iazPmutBah5FxxMQ7hTolP2FREyoQyTfkpm46SDNNYphN24f0H50Iaoc7ZRMhIa27klD0vsLcDDeSDzPsOyA5YBZ80vAfZqtsSUNNQO88bu1k3tiUIMqAqsG0171yQU--6uum2Fqi9ZGe1bTxeHfqMvT3cv-aLcPny-JRnyxC0jIZQmVpZBFQmUqiVqkrAWFtRgTUxT0rJQaRokkjXAFiixDIaD68tJlCnZaJmzOz3guu8d1gXvaOVdV-F4MUunuI3nuIvnh8pHq3Xe2u_LldYHY2HPEbg5gBYD7apnW2B_JHT2sSpMCN3t-dwfHRD6AoPhC1gRQ5hKKqO_r_mGyzfgio</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin</title><source>ScienceDirect Journals</source><creator>Zaidi, Syed A.</creator><creatorcontrib>Zaidi, Syed A.</creatorcontrib><description>We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity reaction, which may be attributable to either or both of the antimicrobial agents used. This gradually resolved over a 4-week time period, with conservative management. A review of the relevant literature on drug-induced hepatotoxicity is also presented.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-200301000-00006</identifier><identifier>PMID: 12544082</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Alanine Transaminase - blood ; Alkaline Phosphatase - blood ; Amoxicillin-Potassium Clavulanate Combination - adverse effects ; Amoxicillin/ clavulanic acid ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury - diagnosis ; Chemical and Drug Induced Liver Injury - etiology ; Chemical and Drug Induced Liver Injury - therapy ; Ciprofloxacin ; Ciprofloxacin - adverse effects ; Drug toxicity and drugs side effects treatment ; Hepatotoxicity ; Humans ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments</subject><ispartof>The American journal of the medical sciences, 2003-01, Vol.325 (1), p.31-33</ispartof><rights>2003 Southern Society for Clinical Investigation</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73</citedby><cites>FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002962915343391$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4024,27923,27924,27925,45780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14486918$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12544082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaidi, Syed A.</creatorcontrib><title>Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity reaction, which may be attributable to either or both of the antimicrobial agents used. This gradually resolved over a 4-week time period, with conservative management. A review of the relevant literature on drug-induced hepatotoxicity is also presented.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alanine Transaminase - blood</subject><subject>Alkaline Phosphatase - blood</subject><subject>Amoxicillin-Potassium Clavulanate Combination - adverse effects</subject><subject>Amoxicillin/ clavulanic acid</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury - diagnosis</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Chemical and Drug Induced Liver Injury - therapy</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - adverse effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Hepatotoxicity</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkE9Pg0AQxTdGY2v1KxguHrH7D1iOSNRqmnjRM1mGIY6hQHZprd9eaqs9OpfJvPzeZOYxFgh-K3iazPmutBah5FxxMQ7hTolP2FREyoQyTfkpm46SDNNYphN24f0H50Iaoc7ZRMhIa27klD0vsLcDDeSDzPsOyA5YBZ80vAfZqtsSUNNQO88bu1k3tiUIMqAqsG0171yQU--6uum2Fqi9ZGe1bTxeHfqMvT3cv-aLcPny-JRnyxC0jIZQmVpZBFQmUqiVqkrAWFtRgTUxT0rJQaRokkjXAFiixDIaD68tJlCnZaJmzOz3guu8d1gXvaOVdV-F4MUunuI3nuIvnh8pHq3Xe2u_LldYHY2HPEbg5gBYD7apnW2B_JHT2sSpMCN3t-dwfHRD6AoPhC1gRQ5hKKqO_r_mGyzfgio</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Zaidi, Syed A.</creator><general>Elsevier Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200301</creationdate><title>Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin</title><author>Zaidi, Syed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alanine Transaminase - blood</topic><topic>Alkaline Phosphatase - blood</topic><topic>Amoxicillin-Potassium Clavulanate Combination - adverse effects</topic><topic>Amoxicillin/ clavulanic acid</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury - diagnosis</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Chemical and Drug Induced Liver Injury - therapy</topic><topic>Ciprofloxacin</topic><topic>Ciprofloxacin - adverse effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Hepatotoxicity</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaidi, Syed A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaidi, Syed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2003-01</date><risdate>2003</risdate><volume>325</volume><issue>1</issue><spage>31</spage><epage>33</epage><pages>31-33</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><coden>AJMSA9</coden><abstract>We describe an elderly patient with normal pre-existing liver functions who was treated with amoxicillin/clavulanic acid and later ciprofloxacin for acute bronchitis. He developed a pattern of liver dysfunction consistent with hepatocellular injury, with clinical features of a hypersensitivity reaction, which may be attributable to either or both of the antimicrobial agents used. This gradually resolved over a 4-week time period, with conservative management. A review of the relevant literature on drug-induced hepatotoxicity is also presented.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>12544082</pmid><doi>10.1097/00000441-200301000-00006</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9629 |
| ispartof | The American journal of the medical sciences, 2003-01, Vol.325 (1), p.31-33 |
| issn | 0002-9629 1538-2990 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00000441_200301000_00006 |
| source | ScienceDirect Journals |
| subjects | Aged Aged, 80 and over Alanine Transaminase - blood Alkaline Phosphatase - blood Amoxicillin-Potassium Clavulanate Combination - adverse effects Amoxicillin/ clavulanic acid Aspartate Aminotransferases - blood Biological and medical sciences Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - therapy Ciprofloxacin Ciprofloxacin - adverse effects Drug toxicity and drugs side effects treatment Hepatotoxicity Humans Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments |
| title | Hepatitis Associated with Amoxicillin/Clavulanic Acid and/or Ciprofloxacin |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A20%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20Associated%20with%20Amoxicillin/Clavulanic%20Acid%20and/or%20Ciprofloxacin&rft.jtitle=The%20American%20journal%20of%20the%20medical%20sciences&rft.au=Zaidi,%20Syed%20A.&rft.date=2003-01&rft.volume=325&rft.issue=1&rft.spage=31&rft.epage=33&rft.pages=31-33&rft.issn=0002-9629&rft.eissn=1538-2990&rft.coden=AJMSA9&rft_id=info:doi/10.1097/00000441-200301000-00006&rft_dat=%3Celsevier_cross%3ES0002962915343391%3C/elsevier_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c425t-38f3aece3853e433dbce64a1dca8607b20c19e8754fccebe2eb5012fae7cf9b73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/12544082&rfr_iscdi=true |