Effect of Silica Exposure on Urinary Excretion of Copper and Zinc

Occupational exposure to silica could lead to renal histological alterations in the glomeruli and proximal tubules. We investigated urinary excretion of copper and zinc and its possible relationship to renal alterations and work duration among nonsmoking, silica-exposed workers. Thirty-six control s...

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Bibliographic Details
Published in:The American journal of the medical sciences 2003-09, Vol.326 (3), p.122-127
Main Authors: EL-Safty, Ibrahim A.M., Gadallah, Mohsen, Shouman, Ahmed E.
Format: Article
Language:English
Subjects:
Adult
Albumins - metabolism
Biological and medical sciences
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
Copper - urine
Creatinine - blood
Creatinine - urine
Glutathione Transferase - metabolism
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Kidney - pathology
Kidney Diseases - metabolism
Kidney Tubules - metabolism
Kidney Tubules - physiology
Liver Diseases - metabolism
Male
Medical sciences
Microalbuminuria
Occupational Exposure
Silica exposure
Silicon Dioxide - adverse effects
Silicon Dioxide - toxicity
Time Factors
Toxicology
Urinary copper
Urinary glutathione S-transferase
Urinary zinc
Urinary α-1-microglobulin
Zinc - chemistry
Zinc - urine
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Summary:Occupational exposure to silica could lead to renal histological alterations in the glomeruli and proximal tubules. We investigated urinary excretion of copper and zinc and its possible relationship to renal alterations and work duration among nonsmoking, silica-exposed workers. Thirty-six control subjects (age, 39.08±6.65years) and 48 silica-exposed workers (age, 36.79±7.33years) were included in the present study. The exposed workers were grouped into workers with
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200309000-00003