Hepatic effects of repeated halothane anesthetics in the hypoxic rat model

The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in th...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1987-09, Vol.67 (3), p.355-360
Main Authors: PLUMMER, J. L, DE LA M. HALL, P, JENNER, M. A, COUSINS, M. J
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Halothane - administration & dosage
Halothane - adverse effects
Hypoxia - pathology
Liver - drug effects
Liver - pathology
Male
Medical sciences
Necrosis
Neuropharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred F344
Time Factors
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Summary:The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period following anesthesia, but was the same after the first, second, and third anesthetics. Rats killed 24 h after a single anesthetic all had centrilobular hepatocellular necrosis. All animals killed 24 h after the second or third anesthetic also had centrilobular necrosis, but, in most animals, this was no more extensive than that following a single anesthetic, regardless of whether the interval between anesthetics was one or five days.
ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198709000-00013