Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations

Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 min...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1998-11, Vol.18 (11), p.1192-1195
Main Authors: Obrist, Walter D., Zhang, Zihong, Yonas, Howard
Format: Article
Language:English
Subjects:
Administration, Inhalation
Biological and medical sciences
Blood Flow Velocity
Brain - blood supply
Brain - diagnostic imaging
Cerebral Arteries - physiology
Cerebrovascular Circulation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Models, Cardiovascular
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Tomography, Emission-Computed - methods
Ultrasonography, Doppler, Transcranial
Xenon Radioisotopes - administration & dosage
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Summary:Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 minutes of sXe inhalation, The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation, In contrast to the peak 35% increase in blood flow velocity during sXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.
ISSN:0271-678X
1559-7016
DOI:10.1097/00004647-199811000-00005