Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations

Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 min...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1998-11, Vol.18 (11), p.1192-1195
Main Authors: Obrist, Walter D., Zhang, Zihong, Yonas, Howard
Format: Article
Language:English
Subjects:
Administration, Inhalation
Biological and medical sciences
Blood Flow Velocity
Brain - blood supply
Brain - diagnostic imaging
Cerebral Arteries - physiology
Cerebrovascular Circulation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Models, Cardiovascular
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Tomography, Emission-Computed - methods
Ultrasonography, Doppler, Transcranial
Xenon Radioisotopes - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913
cites cdi_FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913
container_end_page 1195
container_issue 11
container_start_page 1192
container_title Journal of cerebral blood flow and metabolism
container_volume 18
creator Obrist, Walter D.
Zhang, Zihong
Yonas, Howard
description Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 minutes of sXe inhalation, The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation, In contrast to the peak 35% increase in blood flow velocity during sXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.
doi_str_mv 10.1097/00004647-199811000-00005
format article
fullrecord <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00004647_199811000_00005</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1097_00004647-199811000-00005</sage_id><sourcerecordid>10.1097_00004647-199811000-00005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913</originalsourceid><addsrcrecordid>eNqVUF1PwyAUJUYz5_QnmPTB1yq0pYVHbTY1MfFlJntrbuEyZzpYoNX472UfzmcJCZdzzzkXDiEJo7eMyuqOxlWURZUyKQVj8ZZuIX5CxoxzmVaUladkTLOKpWUlFufkIoSPyBA55yMykoJKTsWY2KkxqPrEmWSB1tn02epBoU5mnftK7lW_-oR-5WwS954wte9gt4zarTdDH4u5W7ulh837d1Kjx9ZDlzx0zh1MaujU0O1cwiU5M9AFvDqcE_I2m87rp_Tl9fG5vn9JVVFkfSp4KVDkgqExgJRnZWZAl5JqEAyQo1FaUMx5BWXB21JpHbGctYC6BcnyCRF7X-VdCB5Ns_GrNfjvhtFmm2Dzm2BzTHAH8Si93ks3Q7tGfRQeIov9m0MfgoLO-JjGKhxpWRGfLatI43tagCU2H27wNn74H-Mt9IPHv_FcRoHMfwCdl5Nf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations</title><source>SAGE Journals Online Archive</source><creator>Obrist, Walter D. ; Zhang, Zihong ; Yonas, Howard</creator><creatorcontrib>Obrist, Walter D. ; Zhang, Zihong ; Yonas, Howard</creatorcontrib><description>Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 minutes of sXe inhalation, The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation, In contrast to the peak 35% increase in blood flow velocity during sXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1097/00004647-199811000-00005</identifier><identifier>PMID: 9809508</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Inhalation ; Biological and medical sciences ; Blood Flow Velocity ; Brain - blood supply ; Brain - diagnostic imaging ; Cerebral Arteries - physiology ; Cerebrovascular Circulation ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Models, Cardiovascular ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Tomography, Emission-Computed - methods ; Ultrasonography, Doppler, Transcranial ; Xenon Radioisotopes - administration &amp; dosage</subject><ispartof>Journal of cerebral blood flow and metabolism, 1998-11, Vol.18 (11), p.1192-1195</ispartof><rights>1998 The International Society of Cerebral Blood Flow and Metabolism</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913</citedby><cites>FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/00004647-199811000-00005$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/00004647-199811000-00005$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21860,27924,27925,44857,45245</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2438197$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9809508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obrist, Walter D.</creatorcontrib><creatorcontrib>Zhang, Zihong</creatorcontrib><creatorcontrib>Yonas, Howard</creatorcontrib><title>Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 minutes of sXe inhalation, The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation, In contrast to the peak 35% increase in blood flow velocity during sXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.</description><subject>Administration, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebral Arteries - physiology</subject><subject>Cerebrovascular Circulation</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Models, Cardiovascular</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Tomography, Emission-Computed - methods</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Xenon Radioisotopes - administration &amp; dosage</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqVUF1PwyAUJUYz5_QnmPTB1yq0pYVHbTY1MfFlJntrbuEyZzpYoNX472UfzmcJCZdzzzkXDiEJo7eMyuqOxlWURZUyKQVj8ZZuIX5CxoxzmVaUladkTLOKpWUlFufkIoSPyBA55yMykoJKTsWY2KkxqPrEmWSB1tn02epBoU5mnftK7lW_-oR-5WwS954wte9gt4zarTdDH4u5W7ulh837d1Kjx9ZDlzx0zh1MaujU0O1cwiU5M9AFvDqcE_I2m87rp_Tl9fG5vn9JVVFkfSp4KVDkgqExgJRnZWZAl5JqEAyQo1FaUMx5BWXB21JpHbGctYC6BcnyCRF7X-VdCB5Ns_GrNfjvhtFmm2Dzm2BzTHAH8Si93ks3Q7tGfRQeIov9m0MfgoLO-JjGKhxpWRGfLatI43tagCU2H27wNn74H-Mt9IPHv_FcRoHMfwCdl5Nf</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Obrist, Walter D.</creator><creator>Zhang, Zihong</creator><creator>Yonas, Howard</creator><general>SAGE Publications</general><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19981101</creationdate><title>Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations</title><author>Obrist, Walter D. ; Zhang, Zihong ; Yonas, Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Cerebral Arteries - physiology</topic><topic>Cerebrovascular Circulation</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Models, Cardiovascular</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Tomography, Emission-Computed - methods</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Xenon Radioisotopes - administration &amp; dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obrist, Walter D.</creatorcontrib><creatorcontrib>Zhang, Zihong</creatorcontrib><creatorcontrib>Yonas, Howard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obrist, Walter D.</au><au>Zhang, Zihong</au><au>Yonas, Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>18</volume><issue>11</issue><spage>1192</spage><epage>1195</epage><pages>1192-1195</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>Computer simulations of stable xenon (sXe) uptake curves were used to evaluate the effect of xenon-induced flow activation on CBF calculations by xenon-enhanced computed tomography, Estimates of flow activation were based on repeated transcranial Doppler measurements of blood velocity during 4,5 minutes of sXe inhalation, The synthetic curves were generated from a generalized Kety equation that included time-varying blood flow activation, In contrast to the peak 35% increase in blood flow velocity during sXe inhalation, a standard analysis of the flow-varying synthetic curves revealed only minor 3% to 5% increases in calculated CBF. It is concluded that brief xenon inhalations can provide blood flow estimates that contain minimal bias from activation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>9809508</pmid><doi>10.1097/00004647-199811000-00005</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0271-678X
ispartof Journal of cerebral blood flow and metabolism, 1998-11, Vol.18 (11), p.1192-1195
issn 0271-678X
1559-7016
language eng
recordid cdi_crossref_primary_10_1097_00004647_199811000_00005
source SAGE Journals Online Archive
subjects Administration, Inhalation
Biological and medical sciences
Blood Flow Velocity
Brain - blood supply
Brain - diagnostic imaging
Cerebral Arteries - physiology
Cerebrovascular Circulation
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Models, Cardiovascular
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Tomography, Emission-Computed - methods
Ultrasonography, Doppler, Transcranial
Xenon Radioisotopes - administration & dosage
title Effect of Xenon-Induced Flow Activation on Xenon-Enhanced Computed Tomography Cerebral Blood Flow Calculations
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T06%3A15%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Xenon-Induced%20Flow%20Activation%20on%20Xenon-Enhanced%20Computed%20Tomography%20Cerebral%20Blood%20Flow%20Calculations&rft.jtitle=Journal%20of%20cerebral%20blood%20flow%20and%20metabolism&rft.au=Obrist,%20Walter%20D.&rft.date=1998-11-01&rft.volume=18&rft.issue=11&rft.spage=1192&rft.epage=1195&rft.pages=1192-1195&rft.issn=0271-678X&rft.eissn=1559-7016&rft.coden=JCBMDN&rft_id=info:doi/10.1097/00004647-199811000-00005&rft_dat=%3Csage_cross%3E10.1097_00004647-199811000-00005%3C/sage_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c442t-8568e8381effae05262fad690da81ae5efcd80e357a645b6cdd5ef31baedba913%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/9809508&rft_sage_id=10.1097_00004647-199811000-00005&rfr_iscdi=true