The poloxamer 407-induced hyperlipidemic atherogenic animal model

We are attempting to develop a chemically-induced murine model for the study of atherosclerosis. Injection of poloxamer-407 (P-407) into rats and mice causes significant dose-dependent hypercholesterolemia and hypertriglyglyceridemia. The elevated triglycerides (TG) seem to result primarily from the...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 1997-11, Vol.29 (11), p.1416-1421
Main Authors: Palmer, W K, Emeson, E E, Johnston, T P
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - chemically induced
Cholesterol - metabolism
Diet
Disease Models, Animal
Dose-Response Relationship, Drug
Hyperlipidemias - chemically induced
Injections, Intravenous
Mice
Mice, Inbred C57BL
Poloxalene
Rats
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Summary:We are attempting to develop a chemically-induced murine model for the study of atherosclerosis. Injection of poloxamer-407 (P-407) into rats and mice causes significant dose-dependent hypercholesterolemia and hypertriglyglyceridemia. The elevated triglycerides (TG) seem to result primarily from the compound's inhibition of lipoprotein lipase. P-407 also indirectly stimulates the activity of the rate limiting enzyme in cholesterol (CHOL) biosynthesis, HMG CoA reductase. In addition, P-407 promotes changes in the concentration of hepatic CHOL content. These date indicate that the hyper CHOL could be the result of increased CHOL synthesis, as well as a clearing of CHOL from the liver. Chronic injection into mice of P-407 for 145 d produced atherogenic lesions in the aortas of C57BL/6 mice. The response was equivalent to that seen in animals eating a high CHOL diet for 145 d. Cholic acid potentiated the P-407-induced atherogenesis. These data suggest that P-407 could be used as an agent for the study of hyperlipidemia-induced atherogenesis.
ISSN:0195-9131
DOI:10.1097/00005768-199711000-00005