Remission of cancer chemotherapy-induced emesis during antidepressant therapy with nefazodone

To emphasize the importance of treating a major depressive episode in an elderly patient with small cell lung cancer (SCLC). A case report is described to illustrate the importance of treating depression in an elderly patient with SCLC undergoing chemotherapy. During the course of antidepressant the...

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Bibliographic Details
Published in:Psychosomatic medicine 1998-01, Vol.60 (1), p.89-91
Main Authors: Khouzam, H R, Monteiro, A J, Gerken, M E
Format: Article
Language:English
Subjects:
Aged
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Small Cell - drug therapy
Carcinoma, Small Cell - psychology
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - psychology
Male
Piperazines
Serotonin Antagonists - adverse effects
Serotonin Antagonists - therapeutic use
Serotonin Uptake Inhibitors - adverse effects
Serotonin Uptake Inhibitors - therapeutic use
Sick Role
Triazoles - adverse effects
Triazoles - therapeutic use
Vomiting - chemically induced
Vomiting - drug therapy
Vomiting - psychology
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Summary:To emphasize the importance of treating a major depressive episode in an elderly patient with small cell lung cancer (SCLC). A case report is described to illustrate the importance of treating depression in an elderly patient with SCLC undergoing chemotherapy. During the course of antidepressant therapy with nefazodone, the patient also experienced a remission of cancer chemotherapy-induced emesis. This case report suggests that the remission of emesis could be related to the 5-hydroxytryptamine (5-HT) antagonistic property of nefazodone.
ISSN:0033-3174
DOI:10.1097/00006842-199801000-00018