Single Dose Enoxacin for the Treatment of Uncomplicated Urogenital Gonorrhea

Enoxacin, a new broad spectrum azaquinolone, has demonstrated in-vitro activity against Neisseria gonorrhoeae including penicillinase producing strains. We evaluated the safety and efficacy of oral enoxacin 400 mg versus intramuscular ceftriaxone 250 mg for the treatment of uncomplicated genital N....

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Bibliographic Details
Published in:Sexually transmitted diseases 1989-04, Vol.16 (2), p.114-117
Main Authors: ALBRECHT, LISA M., RYBAK, MICHAEL J., SCHUBINER, HOWARD H., WEINER, LAWRENCE M.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ceftriaxone - adverse effects
Ceftriaxone - therapeutic use
Clinical Trials as Topic
Enoxacin - administration & dosage
Enoxacin - adverse effects
Enoxacin - therapeutic use
Female
Gonorrhea - drug therapy
Humans
Male
Medical sciences
Neisseria gonorrhoeae
Original Articles
Pharmacology. Drug treatments
Random Allocation
Urogenital System - microbiology
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Summary:Enoxacin, a new broad spectrum azaquinolone, has demonstrated in-vitro activity against Neisseria gonorrhoeae including penicillinase producing strains. We evaluated the safety and efficacy of oral enoxacin 400 mg versus intramuscular ceftriaxone 250 mg for the treatment of uncomplicated genital N. gonorrhoeae infections. Of the 57 patients enrolled, 48 patients (26 men, 22 women) were culture positive and returned for the follow up visit. Six patients (12.5%) had penicillinase producing strains of N. gonorrhoeae, and eleven patients (23%) had concomitant Chlamydia trachomatis infections. Genital gonorrhea was eradicated in 98% of the patients, with a cure rate of 22/23 (96%) in the enoxacin group and 25/25 (100%) in the ceftriaxone group. There were no consequential side effects noted for either agent. Oral enoxacin is a safe and efficacious alternative for the treatment of uncomplicated N. gonorrhoeae infections.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-198904000-00014