The Spermicide Nonoxynol-9 Does Not Inactivate Papillomavirus

Vaginal spermicides are effective contraceptives, and are also capable of inactivating many sexually transmitted pathogens by their detergent effect on bacterial cell membranes and viral envelopes. A 5% concentration of nonoxynol-9, the most frequently used active ingredient of spermicides, was test...

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Bibliographic Details
Published in:Sexually transmitted diseases 1992-07, Vol.19 (4), p.203-205
Main Authors: HERMONAT, PAUL L., DANIEL, RICHARD W., SHAH, KEERTI V.
Format: Article
Language:English
Subjects:
Animals
Cell Transformation, Viral - drug effects
Cytomegalovirus - pathogenicity
In Vitro Techniques
Mice
Nonoxynol - pharmacology
Papillomaviridae - drug effects
Papillomaviridae - pathogenicity
Spermatocidal Agents - pharmacology
Tumor Virus Infections - prevention & control
Virulence - drug effects
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Summary:Vaginal spermicides are effective contraceptives, and are also capable of inactivating many sexually transmitted pathogens by their detergent effect on bacterial cell membranes and viral envelopes. A 5% concentration of nonoxynol-9, the most frequently used active ingredient of spermicides, was tested for its ability to reduce the transforming activity of bovine papillomavirus type 1 (BPV-1), and the infectivity of BK virus (BKV) and cytomegalovirus (CMV). Nonoxynol-9 markedly reduced the infectivity of CMV, an enveloped virus, but did not significantly affect the activity of the nonenveloped viruses BPV-1 and BKV. Papillomavirus infections are strongly implicated in the etiology of cervical cancer. The reported protective effect of vaginal spermicides against cervical cancer is very likely not mediated by direct inactivation of papillomaviruses by the spermicide.
ISSN:0148-5717
1537-4521
DOI:10.1097/00007435-199207000-00004