Glycine reduces the inflammatory response and organ damage in a two-hit sepsis model in rats

The goal of this study was to investigate whether prefeeding of glycine reduces the immunoinflammatory response, the degree of distant organ injury (liver), and/or the mortality rate in a two-hit model using intestinal ischemia/reperfusion and endotoxin (ET) challenge 6 h later in rats. The liver da...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2001-08, Vol.16 (2), p.116-121
Main Authors: GROTZ, Martin Rolf, PAPE, Hans-Christoph, VAN GRIENSVEN, Martijn, STALP, Michael, ROHDE, Frank, BOCK, T. Daniel, KRETTEK, Christian
Format: Article
Language:English
Subjects:
Amino Acids - blood
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Cytokines - blood
Cytokines - genetics
Disease Models, Animal
Emergency and intensive care: infection, septic shock
Endotoxins - toxicity
Glycine - blood
Glycine - pharmacology
Glycine - therapeutic use
Inflammation - prevention & control
Intensive care medicine
Liver Function Tests
Male
Medical sciences
Rats
Rats, Sprague-Dawley
Sepsis - blood
Sepsis - drug therapy
Sepsis - mortality
Sepsis - physiopathology
Transcription, Genetic
Weight Gain
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Summary:The goal of this study was to investigate whether prefeeding of glycine reduces the immunoinflammatory response, the degree of distant organ injury (liver), and/or the mortality rate in a two-hit model using intestinal ischemia/reperfusion and endotoxin (ET) challenge 6 h later in rats. The liver damage was greatest at 24 h after ET challenge and completely inhibited by glycine. The early systemic increase of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL) -6 as well as the secretion of the antiinflammatory cytokine IL-10 was reduced by glycine. Tissue cytokine mRNA expression (TNF-alpha, IL-1beta, IL-10) was decreased in the lung and the liver but not in the mesenteric lymph node or ileum, in the glycine-fed group. However, glycine did not decrease the mortality rate. These results suggest that prefeeding of glycine reduces liver damage as well as the systemic and local (lung and liver) inflammatory response after intestinal ischemia/reperfusion and endotoxin challenge in rats.
ISSN:1073-2322
1540-0514
DOI:10.1097/00024382-200116020-00006