Assessing basophil function

Basophils play an important and non-redundant role as inductor and effector cells of the Th2 response, e.g., helminth infection. In addition, they are involved in a broadening range of pathological conditions including systemic lupus erythematosus, eosinophilic oesophagitis and IgG-mediated systemic...

Full description

Saved in:
Bibliographic Details
Published in:Pathology 2014, Vol.46, p.S39-S39
Main Authors: Headley, Alexander, Katelaris, Connie, Adelstein, Stephen
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Basophils play an important and non-redundant role as inductor and effector cells of the Th2 response, e.g., helminth infection. In addition, they are involved in a broadening range of pathological conditions including systemic lupus erythematosus, eosinophilic oesophagitis and IgG-mediated systemic anaphylaxis. There is a real need to develop robust in vitro techniques to enable study their role in human disease. Basophil histamine release, sulfidoleukotriene synthesis and the flow cytometric basophil activation test are three methods for diagnosing IgE-mediated allergy in vitro. This talk will describe the potential application of these tests in both allergic and non-allergic contexts, as well as outlining challenges in the performance and interpretation of these functional assays.
ISSN:0031-3025
1465-3931
DOI:10.1097/01.PAT.0000443487.35411.87