1. Angiofibroma of soft tissue: 2 case reports

Angiofibroma of soft tissue is a distinct benign tumour with fibroblastic morphology and a prominent vascular network which was first described in 2012 in a series of 37 cases. The morphological hallmark is marked by a proliferation of uniform, bland spindle cells and complex vascular pattern within...

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Bibliographic Details
Published in:Pathology 2014, Vol.46, p.S107-S107
Main Authors: Adhikari, C., Mahar, A., Singh, N., Stalley, P., Wilsher, M., Bonar, F.
Format: Article
Language:English
Online Access:Get full text
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Summary:Angiofibroma of soft tissue is a distinct benign tumour with fibroblastic morphology and a prominent vascular network which was first described in 2012 in a series of 37 cases. The morphological hallmark is marked by a proliferation of uniform, bland spindle cells and complex vascular pattern within a variably myxoid to collagenous stroma. It is also cytogenetically characterised by t(5;8) translocation and AHRR-NCOA2 gene rearrangement. It has a low rate of local recurrence and no evidence of metastasis following surgical excision. We report two similar cases of this condition one of which had t(5;8) translocation. Being a newly described entity it is important to identify this tumour from other differential diagnosis like cellular angiofibroma, low-grade myxofibrosarcoma, low-grade fibromyxoid sarcoma, solitary fibrous tumour and myxoid liposarcoma depending on the clinical context to avoid any misdiagnosis.
ISSN:0031-3025
1465-3931
DOI:10.1097/01.PAT.0000443691.04824.a4