Smoking, apolipoprotein E genotype, and early onset of coronary heart disease

Background We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD). Design and methods Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30–70 years were assessed with respect to age at onset of CHD. Results The a...

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Bibliographic Details
Published in:European journal of cardiovascular prevention and rehabilitation 2005-06, Vol.12 (3), p.268-270
Main Authors: Loew, Michael, Hoffmann, Michael M., Hahmann, Harry, März, Winfried, Rothenbacher, Dietrich, Brenner, Hermann
Format: Article
Language:English
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Summary:Background We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD). Design and methods Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30–70 years were assessed with respect to age at onset of CHD. Results The adjusted odds ratio for early onset of CHD (< 55 years) was 1.86 (95% confidence interval, 1.31–2.62) for smokers compared to non-smokers. The ApoE genotype had no significant influence and there was no significant interaction between ApoE genotype and smoking. Conclusion We found smoking but not ApoE genotype to be an independent risk factor for early onset of CHD.
ISSN:2047-4873
1741-8267
2047-4881
1741-8275
DOI:10.1097/01.hjr.0000160599.57009.aa