Chronic Hypersensitivity Pneumonitis With Heart Involvement Observed During In-111 DTPA Octreotide (OctreoScan®) Imaging

An 80-year-old farmer with unresectable hepatocellular carcinoma was referred to the authors’ department for evaluation of the somatostatin receptor status of his tumor. After intravenous administration of In-111 gadolinium–diethylenetriame pentaacetic acid (DTPA) octreotide (OctreoScan®, 5 mCi), th...

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Bibliographic Details
Published in:Clinical nuclear medicine 2003-12, Vol.28 (12), p.994-995
Main Authors: Zanglis, Adonios, Andreopoulos, Demetrios, Zissimopoulos, Athanassios, Baziotis, Nikolaos
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - diagnostic imaging
Abdominal Neoplasms - secondary
Aged
Aged, 80 and over
Biological and medical sciences
Bird Fancier's Lung - diagnostic imaging
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - secondary
Chronic Disease
Diagnosis, Differential
Heart - diagnostic imaging
Humans
Incidental Findings
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Lung - diagnostic imaging
Male
Medical sciences
Myocarditis - diagnostic imaging
Octreotide - analogs & derivatives
Pentetic Acid - analogs & derivatives
Radionuclide Imaging
Radiopharmaceuticals
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:An 80-year-old farmer with unresectable hepatocellular carcinoma was referred to the authors’ department for evaluation of the somatostatin receptor status of his tumor. After intravenous administration of In-111 gadolinium–diethylenetriame pentaacetic acid (DTPA) octreotide (OctreoScan®, 5 mCi), the patient was imaged 24 hours and 48 hours later. Besides the presence of somatostatin receptors in his primary tumor and 1 intraabdominal metastatic site, diffuse pulmonary and heart uptake was observed. A review of the patient's history revealed that he had pulmonary fibrosis, resulting from hypersensitivity pneumonitis, secondary to his occupational exposure to chicken-derived antigens. The activated lymphocytic pulmonary and heart infiltration is the most likely explanation for the observed In-111 DTPA octreotide uptake.
ISSN:0363-9762
1536-0229
DOI:10.1097/01.rlu.0000100104.46990.e4