Quorum sensing: An emerging role for Vibrio infection and host defense

• Published in: Infectious microbes & diseases 2024-06
• Main Authors: Lin, Hao-Nan, Huang, Xian-Hui, Miao, Xin-Jun, Hu, Wei-Lin, Lou, Yong-Liang, Xie, Dan-Li
• Format: Article
• Language: English
• ISSN: 2641-5917; 2641-5917
• DOI: 10.1097/IM9.0000000000000143

Quorum sensing (QS) is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting, sensing and responding to signaling molecules called autoinducers (AIs). In Vibrio species, QS plays a crucial role in modulating different biological characteristics. QS can influence the formation of biofilms, which are communities of bacteria encased in a protective matrix. It also controls flagella formation and motility, ensuring that Vibrio spp. can move efficiently in response to environmental cues. Additionally, QS in Vibrio spp. regulates the production of different virulence factors based on cell density. This enables the bacteria to adjust their virulence strategies accordingly, enhancing pathogenicity. QS also influences the interaction between Vibrio spp. and their host. Following infection by Vibrio spp., QS can affect the host immune response and colonization processes. Understanding the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio spp. and the host. In summary, research on QS in Vibrio spp. has revealed its significance in regulating various biological phenotypes, controlling virulence factor production and affecting host defense. It provides valuable insights into the intricate mechanisms underlying microbial behavior, host adaptation and Vibrio spp. pathogenesis.