Spontaneous Nasal Septal Perforation With Antiangiogenic Bevacizumab Therapy

Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies. This case describes a 52‐year‐old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic dru...

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Bibliographic Details
Published in:The Laryngoscope 2008-09, Vol.118 (9), p.1539-1541
Main Authors: Burkart, Collin M., Grisel, Jedidiah J., Hom, David B.
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - adverse effects
Angiogenesis Inhibitors - therapeutic use
antiangiogenic therapy
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Bevacizumab
Biological and medical sciences
Diagnosis, Differential
Endoscopy
Female
Follow-Up Studies
Humans
Medical sciences
Middle Aged
Nasal septal perforation
Nasal Septum - drug effects
Nasal Septum - pathology
Nose Diseases - chemically induced
Nose Diseases - diagnosis
Otorhinolaryngology. Stomatology
Ovarian Neoplasms - drug therapy
Rupture, Spontaneous
Vascular Endothelial Growth Factor A
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Summary:Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies. This case describes a 52‐year‐old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment. Bevacizumab is a recently developed monoclonal antibody against vascular endothelial growth factor receptor used to inhibit angiogenesis. The patient was ultimately treated with a nasal septal button with good symptom relief. This case documents the first report in the otolaryngology literature describing this new etiology for nasal septal perforations.
ISSN:0023-852X
1531-4995
DOI:10.1097/MLG.0b013e31817c4296