Nonmalignant 68Ga-FAPI-46 Uptake in 2 Cases of TENIS Syndrome: Comparison With 18F-FDG

The cancer specificity of fibroblast activation protein inhibitor (FAPI) uptake remains understudied topic, and several cases of false-positive FAPI PET/CT findings have been reported. We present 2 patients of differentiated thyroid cancer with thyroglobulin elevation and negative iodine scintigraph...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-05, Vol.49 (5), p.e213-e214
Main Authors: Karamian, Farivash, Sadeghi, Ramin, Aghaee, Atena, Askari, Emran, Roustaei, Hessamoddin
Format: Article
Language:English
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Summary:The cancer specificity of fibroblast activation protein inhibitor (FAPI) uptake remains understudied topic, and several cases of false-positive FAPI PET/CT findings have been reported. We present 2 patients of differentiated thyroid cancer with thyroglobulin elevation and negative iodine scintigraphy syndrome who underwent 68Ga-FAPI PET/CT and 18F-FDG PET/CT for evaluation of any possible sites for metastatic disease. Although no focus of metastatic disease was found in these patients, remarkable findings were noticed instead. Nonmalignant FAPI uptake was evident in the gallbladder, uterus, and degenerative changes, whereas these uptake were discordant or partially concordant with those in FDG's, also CT images showed no underlying abnormality.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000005160