Impact of terlipressin on renal graft function

To assess the effect of a bolus of terlipressin in brain-dead donors with shock refractory to norepinephrine, a retrospective study was conducted in a 16-bed intensive care unit of a university hospital. Twenty brain-dead donors were treated with norepinephrine within the study period. Nine of these...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2008-06, Vol.29 (6), p.667-669
Main Authors: Blasco, Valéry, Leone, Marc, Geissler, Alain, Antonini, François, Albanèse, Jacques, Martin, Claude
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensive Agents - administration & dosage
Brain Death - blood
Brain Death - physiopathology
Creatinine - blood
Female
Graft Survival - drug effects
Humans
Hypotension - blood
Hypotension - chemically induced
Kidney - metabolism
Kidney - physiopathology
Kidney Transplantation
Liver - metabolism
Liver - physiopathology
Lypressin - administration & dosage
Lypressin - analogs & derivatives
Male
Middle Aged
Norepinephrine - administration & dosage
Norepinephrine - adverse effects
Recovery of Function - drug effects
Retrospective Studies
Shock - blood
Shock - chemically induced
Transplantation, Homologous
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Summary:To assess the effect of a bolus of terlipressin in brain-dead donors with shock refractory to norepinephrine, a retrospective study was conducted in a 16-bed intensive care unit of a university hospital. Twenty brain-dead donors were treated with norepinephrine within the study period. Nine of these donors developed persisting hypotension (MAP < 65 mmHg) not responding to fluid loading and high dose of norepinephrine. They were then treated with a single bolus of terlipressin (1 mg). This resulted in a MAP rise from 58 +/- 10 to 93 +/- 20 mmHg (P = 0.009). One month after transplantation, no differences were observed in serum creatinine levels of the recipients who received a renal transplant extracted from donors responding or not to norepinephrine (138 +/- 43 vs. 137 +/- 43 microM; P = 0.95). The liver function was similar in both groups. Within the limitations of this study, a single bolus of terlipressin in norepinephrine-resistant vasodilatory shock donors does not affect the renal and liver graft quality in the recipients.
ISSN:1073-2322
DOI:10.1097/SHK.0b013e31815d0ae7