An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. However, it is not yet fully understood how the physico-chemical properties of the nanoparticles influence cellular association and uptake. Cellular association experiments...

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Bibliographic Details
Published in:Journal of the Royal Society interface 2018-07, Vol.15 (144), p.20180364-20180364
Main Authors: Johnston, Stuart T., Faria, Matthew, Crampin, Edmund J.
Format: Article
Language:English
Subjects:
Cellular Association
Chemical compounds
Chemical properties
Delivered Dose
Diagnostic systems
Diffusion
Dosage
Life Sciences–Mathematics interface
Nanoparticles
Organic chemistry
Pharmacology
Physicochemical properties
Polydispersity
Sedimentation
Transport
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Summary:Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. However, it is not yet fully understood how the physico-chemical properties of the nanoparticles influence cellular association and uptake. Cellular association experiments are routinely performed in an effort to determine how nanoparticle properties impact the rate of nanoparticle–cell association. To compare experiments in a meaningful manner, the association data must be normalized by the amount of nanoparticles that arrive at the cells, a measure referred to as the delivered dose. The delivered dose is calculated from a model of nanoparticle transport through fluid. A standard assumption is that all nanoparticles within the population are monodisperse, namely the nanoparticles have the same physico-chemical properties. We present a semi-analytic solution to a modified model of nanoparticle transport that allows for the nanoparticle population to be polydisperse. This solution allows us to efficiently analyse the influence of polydispersity on the delivered dose. Combining characterization data obtained from a range of commonly used nanoparticles and our model, we find that the delivered dose changes by more than a factor of 2 if realistic amounts of polydispersity are considered.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2018.0364