Cardiovascular Disease and Trace Metals [and Discussion]

Cardiovascular disease is a major cause of morbidity and mortality in the U.K. and other developed countries. In the U.K., mortality from coronary heart disease has increased progressively over the past 25 years, particularly in males. This paper examines the possible role of trace metals in the dev...

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Bibliographic Details
Published in:Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1979-07, Vol.205 (1158), p.135-143
Main Authors: Shaper, A. G., Kazantzis, G., Schoental, R.
Format: Article
Language:English
Subjects:
Blood
Blood Pressure
Cadmium
Cadmium Poisoning - physiopathology
Cardiomyopathies
Cardiovascular diseases
Cardiovascular Diseases - chemically induced
Cardiovascular Diseases - mortality
Cobalt
Cobalt - poisoning
Environmental Pollutants - adverse effects
Heart diseases
Humans
Hypertension
Lead
Lead Poisoning - physiopathology
Metals - adverse effects
Mortality
United Kingdom
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Summary:Cardiovascular disease is a major cause of morbidity and mortality in the U.K. and other developed countries. In the U.K., mortality from coronary heart disease has increased progressively over the past 25 years, particularly in males. This paper examines the possible role of trace metals in the development of cardiovascular disease, with particular reference to the effects of cobalt, cadmium and lead in myocardial disease, atherosclerosis and hypertension. It is concluded that cobalt is an unimportant factor in community levels of cardiovascular disease, that cadmium has striking effects on blood pressure in animals and that there is some evidence for an association between environmental lead and high blood pressure.
ISSN:0962-8452
0080-4649
0950-1193
1471-2954
2053-9193
DOI:10.1098/rspb.1979.0054