Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates

• Published in: Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2010-01, Vol.277 (1678), p.57-63
• Main Authors: Roney, James R., Simmons, Zachary L., Lukaszewski, Aaron W.
• Format: Article
• Language: English
• Subjects: Adolescent; Androgen Receptor Gene; Androgen receptors; Cortisol; DNA - chemistry; DNA - genetics; Female; Genetic Variation - physiology; Genotype; Glucocorticoids; Hormones; Human Mating; Human sexual behavior; Humans; Hydrocortisone - physiology; Male; Mating behavior; Men; Opposite gender interaction; Polymerase Chain Reaction; Polymorphism, Genetic - physiology; Random Allocation; Receptors, Androgen - genetics; Receptors, Androgen - physiology; Regression Analysis; Saliva - chemistry; Sexual Behavior - physiology; Social interaction; Testosterone; Testosterone - physiology; Trinucleotide Repeats - genetics; Young Adult
• ISSN: 0962-8452; 1471-2954; 1471-2945
• DOI: 10.1098/rspb.2009.1538

Exposure to potential mates triggers rapid elevations of testosterone and glucocorticoid concentrations in males of many non-human species, and preliminary studies support similar effects in human males. The human studies have all reported large individual differences in these responses, however, and the present study tested whether specific biological variables may help explain these differences. Replicating past research, the present study found that men's salivary testosterone and cortisol concentrations increased after a brief conversation with a young woman, but did not change (or slightly decreased) after a conversation with a young man. In addition, smaller numbers of CAG repeats in men's androgen receptor gene, and lower baseline cortisol concentrations, each predicted larger testosterone responses to the interactions with women. The CAG repeat finding demonstrates that a specific genetic polymorphism predicts physiological responses to social interactions that may in turn have important downstream consequences on men's mating behaviour. The effects of cortisol are consistent with past demonstrations of glucocorticoid inhibition of testosterone production and show that such inhibition also affects testosterone responses to social stimuli. In sum, the present study both confirms men's hormonal reactions to potential mates and identifies novel biological variables that predict individual differences in these responses.