Novel Neurospora crassa mutants with altered synthesis of polyunsaturated fatty acids

Five new mutants of Neurospora crassa that require supplementation with unsaturated fatty acids have been isolated. The mutants, designated pfa, are impaired in the synthesis of the polyunsaturated fatty acids alpha-linoleic or alpha-linolenic acid, but are able to synthesize oleic acid. The pfa mut...

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Bibliographic Details
Published in:Microbiology (Society for General Microbiology) 1995-09, Vol.141 (9), p.2307-2314
Main Authors: Goodrich-Tanrikulu, M, Lin, J.T, Stafford, A.E, Markapugay, M.I, McKeon, T.A, Fuller, G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
Mycology
plant biochemistry
plant physiology
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Summary:Five new mutants of Neurospora crassa that require supplementation with unsaturated fatty acids have been isolated. The mutants, designated pfa, are impaired in the synthesis of the polyunsaturated fatty acids alpha-linoleic or alpha-linolenic acid, but are able to synthesize oleic acid. The pfa mutants are thus distinct from previously described ufa mutants, which are unable to synthesize oleic acid. The five pfa mutants map to distinct loci, and have characteristic patterns of incorporation of [14C]acetate and [14C]oleate into their fatty acids.
ISSN:1350-0872
1465-2080
DOI:10.1099/13500872-141-9-2307