Impact of Integrase Inhibitors on Weight

Current evidence suggests that Integrase Strand Transfer Inhibitors (INSTI) are associated with excess weight gain. These increases are particularly significant for black people and women. Clinic notes of 84 patients stable on INSTI for at least 18 months and attending HIV outpatient clinics at Cast...

Full description

Saved in:
Bibliographic Details
Published in:Access microbiology 2020-02, Vol.2 (2)
Main Authors: Varadarajan, Maithili, Thaker, Hiten, Samson, Anda, Adams, Kate, Harrison, Sarah, Cullen, Lorraine
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Current evidence suggests that Integrase Strand Transfer Inhibitors (INSTI) are associated with excess weight gain. These increases are particularly significant for black people and women. Clinic notes of 84 patients stable on INSTI for at least 18 months and attending HIV outpatient clinics at Castle Hill Hospital, Hull Royal Infirmary, Grimsby Hospital and Scunthorpe Hospital were included. Data including height and weight was collected at 18, 30, 42 and 54 months, following commencement of INSTI. Statistical analysis was performed using STATA. 65% of patients were male. The mean age at baseline was 50 and the mean age at diagnosis was 40. Median CD4 count was 669 and viral load was 0 within the last 6 months. 64% of patients were White British, 7% White Other, 21% Black and 9% other. At 30 months, mean weight increased by 1.41kg, statistically significant at p
ISSN:2516-8290
2516-8290
DOI:10.1099/acmi.fis2019.po0069