Pt electrode modified with β-cyclodextrin/polyaniline for electrochemical sensing of penicillin V

Purpose A new electrochemical analysis based on ß-cyclodextrin (ß-CD) was developed for penicillin V (Peni-V) using polyaniline as a conducting polymer. Design/methodology/approach The preparation of modified electrode involves the incorporation of β-CD with membrane of polyaniline. Polyaniline, inc...

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Bibliographic Details
Published in:Sensor review 2020-05, Vol.40 (2), p.247-254
Main Authors: Djaalab, Elbahi, Samar, Mohamed Elhadi, Zougar, Saida, Kherrat, Rochdi
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Chemical properties
Chemical sensors
Conducting polymers
Cyclodextrins
Design modifications
Drug resistance
Electrochemical analysis
Electrodes
Experiments
Microorganisms
Nanostructured materials
Penicillin
Pharmaceutical industry
Polyanilines
Polymerization
Silver chloride
Software
Spectrum analysis
Voltammetry
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Summary:Purpose A new electrochemical analysis based on ß-cyclodextrin (ß-CD) was developed for penicillin V (Peni-V) using polyaniline as a conducting polymer. Design/methodology/approach The preparation of modified electrode involves the incorporation of β-CD with membrane of polyaniline. Polyaniline, incorporating β-CD, was prepared by electrochemical polymerization method in a medium of hypochloride. Cyclic voltammetry and electrochemical impedance have been used to characterize this sensor. The detection and the kinetic study of modified platinum electrode are evaluated. Findings Results clearly indicate that β-CDs interfere with the polymerization mechanism with an inhibition factor. The inclusion phenomenon of β-CDs has been studied and applied to detect Peni-V. The principle of this electrochemical sensor is based on the chemical properties of β-CD, which were studied using the cyclic voltammetric method and impedance spectroscopy. The electrochemical behavior of Peni-V at concentrations between 10–8 and 10–2 M was measured versus Ag/AgCl at pH 7.4 and 30°C in a phosphate alkaline buffer. Relationship of Peni-V concentration in logarithmic mathematical form with current in potentiometric method and with resistance in impedimetric method were obtained. Originality/value The present study showed that the Pt electrode modified with Polyaniline–β-CD was an excellent candidate for sensitive penicillin analysis. The proposed electroanalytical technique is rapid, simple and inexpensive.
ISSN:0260-2288
1758-6828
DOI:10.1108/SR-10-2018-0251