Convolutional Neural Network With Sparse Strategies to Classify Dynamic Functional Connectivity

Classification of dynamic functional connectivity (DFC) is becoming a promising approach for diagnosing various neurodegenerative diseases. However, the existing methods generally face the problem of overfitting. To solve it, this paper proposes a convolutional neural network with three sparse strat...

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Bibliographic Details
Published in:IEEE journal of biomedical and health informatics 2022-03, Vol.26 (3), p.1219-1228
Main Authors: Ji, Junzhong, Chen, Zhihui, Yang, Cuicui
Format: Article
Language:English
Subjects:
Artificial neural networks
Brain - diagnostic imaging
Brain mapping
Brain Mapping - methods
Classification
Convolutional neural network
Diseases
dynamic functional connectivity
Feature extraction
Functional magnetic resonance imaging
Humans
Magnetic Resonance Imaging - methods
Neural networks
Neural Networks, Computer
Neurodegenerative diseases
Optimization
resting-state functional Magnetic Resonance Imaging (rs-fMRI)
Sparse matrices
sparse strategies
Symmetric matrices
Temporal variations
Time series analysis
Windows
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Summary:Classification of dynamic functional connectivity (DFC) is becoming a promising approach for diagnosing various neurodegenerative diseases. However, the existing methods generally face the problem of overfitting. To solve it, this paper proposes a convolutional neural network with three sparse strategies named SCNN to classify DFC. Firstly, an element-wise filter is designed to impose sparse constraints on the DFC matrix by replacing the redundant elements with zeroes, where the DFC matrix is specially constructed to quantify the spatial and temporal variation of DFC. Secondly, a 1×1 convolutional filter is adopted to reduce the dimensionality of the sparse DFC matrix, and remove meaningless features resulted from zero elements in the subsequent convolution process. Finally, an extra sparse optimization classifier is employed to optimize the parameters of the above two filters, which can effectively improve the ability of SCNN to extract discriminative features. Experimental results on multiple resting-state fMRI datasets demonstrate that the proposed model provides a better classification performance of DFC compared with several state-of-the-art methods, and can identify the abnormal brain functional connectivity.
ISSN:2168-2194
2168-2208
DOI:10.1109/JBHI.2021.3100559