RAVIR: A Dataset and Methodology for the Semantic Segmentation and Quantitative Analysis of Retinal Arteries and Veins in Infrared Reflectance Imaging

• Published in: IEEE journal of biomedical and health informatics 2022-07, Vol.26 (7), p.3272-3283
• Main Authors: Hatamizadeh, Ali, Hosseini, Hamid, Patel, Niraj, Choi, Jinseo, Pole, Cameron C., Hoeferlin, Cory M., Schwartz, Steven D., Terzopoulos, Demetri
• Format: Article
• Language: English
• Subjects: Arteries; Benchmarks; Biomarkers; Blood vessels; Color imagery; Color vision; Computer vision; Datasets; Deep learning; Diabetes mellitus; Diseases; Distillation; Hypertension; Image color analysis; Image processing; Image segmentation; Imaging; Infrared analysis; Infrared imaging; Infrared reflection; Medical imaging; Microvasculature; ophthalmology; Quantitative analysis; Reflectance; Retina; Retinal image analysis; Retinal images; Retinal vessels; Semantic segmentation; Semantics; Vascular diseases; vascular width estimation; Veins; Veins & arteries
• ISSN: 2168-2194; 2168-2208
• DOI: 10.1109/JBHI.2022.3163352

The retinal vasculature provides important clues in the diagnosis and monitoring of systemic diseases including hypertension and diabetes. The microvascular system is of primary involvement in such conditions, and the retina is the only anatomical site where the microvasculature can be directly observed. The objective assessment of retinal vessels has long been considered a surrogate biomarker for systemic vascular diseases, and with recent advancements in retinal imaging and computer vision technologies, this topic has become the subject of renewed attention. In this paper, we present a novel dataset, dubbed RAVIR, for the semantic segmentation of Retinal Arteries and Veins in Infrared Reflectance (IR) imaging. It enables the creation of deep learning-based models that distinguish extracted vessel type without extensive post-processing. We propose a novel deep learning-based methodology, denoted as SegRAVIR, for the semantic segmentation of retinal arteries and veins and the quantitative measurement of the widths of segmented vessels. Our extensive experiments validate the effectiveness of SegRAVIR and demonstrate its superior performance in comparison to state-of-the-art models. Additionally, we propose a knowledge distillation framework for the domain adaptation of RAVIR pretrained networks on color images. We demonstrate that our pretraining procedure yields new state-of-the-art benchmarks on the DRIVE, STARE, and CHASE_DB1 datasets. Dataset link: https://ravirdataset.github.io/data .