A Multifunctional Smart Soft Contact Lens Device Enabled by Nanopore Thin Film for Glaucoma Diagnostics and In Situ Drug Delivery

In this paper, we report a new power-free multifunctional soft contact lens device that can measure intraocular pressure (IOP), achieve extended drug delivery in situ, and detect glaucoma biomarkers, all within the same device. Experiments demonstrate that the contact lens sensor can detect Interleu...

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Bibliographic Details
Published in:Journal of microelectromechanical systems 2019-10, Vol.28 (5), p.810-816
Main Authors: Song, Chao, Ben-Shlomo, Gil, Que, Long
Format: Article
Language:English
Subjects:
biomarker for ocular diseases
Biomarkers
Biomedical optical imaging
Contact lens device
Contact lenses
Contact pressure
Drug delivery systems
drug release
Drugs
Glaucoma
Interleukins
Intraocular pressure
Lenses
nanopore thin film
Optical device fabrication
Optical sensors
Porosity
Thin films
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Summary:In this paper, we report a new power-free multifunctional soft contact lens device that can measure intraocular pressure (IOP), achieve extended drug delivery in situ, and detect glaucoma biomarkers, all within the same device. Experiments demonstrate that the contact lens sensor can detect Interleukin 12p70, one possible biomarker for glaucoma, in a concentration as low as 2 pg/ml in artificial tears. The sustained drug release of the contact lens device can last up to 30 days. In ex vivo tests using cadaver pig eyes, the sensor detected IOP in a range of 10-50 mmHg with excellent repeatability.
ISSN:1057-7157
1941-0158
DOI:10.1109/JMEMS.2019.2927232