A Fluorescent Micro-Optofluidic Sensor for In-Line Ion Selective Electrolyte Monitoring

In-line electrolyte monitoring during hemodialysis treatment is an important step towards personalized treatment, for optimization of clinical blood pressure management and minimization of cardiovascular complications and bone-mineral disease. But how to achieve such in-line measurement? We propose...

Full description

Saved in:
Bibliographic Details
Published in:IEEE sensors journal 2018-05, Vol.18 (10), p.3946-3951
Main Authors: Sharma, Manoj K., Gostl, Robert, Frijns, Arjan J. H., Wieringa, Fokko P., Kooman, Jeroen P., Sijbesma, Rint P., Smeulders, David M. J.
Format: Article
Language:English
Subjects:
Blood pressure
Dialysis
Disease control
Electrolytes
Electron transfer
Fluorescence
in-line monitoring
Microchannels
Microfluidics
Monitoring
Optical fibers
optical sensor
Optical sensors
photoinduced electron transfer
Polydimethylsiloxane
Silicone resins
Sodium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In-line electrolyte monitoring during hemodialysis treatment is an important step towards personalized treatment, for optimization of clinical blood pressure management and minimization of cardiovascular complications and bone-mineral disease. But how to achieve such in-line measurement? We propose a real-time electrolyte measurement system based on a molecular fluorescence "on-off" switching mechanism. We have fabricated a disposable polymeric micro-optofluidic device in polydimethylsiloxane (PDMS) with integrated optical fibers to enable in-line electrolyte monitoring. The sensing principle is based on photoinduced electron transfer (PET) that ion-selectively quenches the fluorescence of a molecular optical probe. The PET molecules are covalently immobilized onto the PDMS microchannel walls. As a proof-of-concept, we determine sodium concentration in a flowing medium. A clear relation between fluorescence intensity and sodium concentration is observed. The PET principle can also be applied to many other ion types.
ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2018.2816986