A Novel SERS Substrate Containing Silver Nanoparticle-Deposited Photoresist Microcone Array for Sensitive Biosensing

In this study, we developed a novel surface-enhanced Raman scattering (SERS) substrate formed by depositing silver nanoparticles (AgNPs) on a silver thin film-coated photoresist (PR) microcone array. The semiconductor photolithographic process was adopted for fabricating the PR microcone array. The...

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Bibliographic Details
Published in:IEEE sensors journal 2024-01, Vol.24 (2), p.1-1
Main Authors: Lin, Ying-Ting, Wang, Sheng-Hsiang, Tseng, Yu-Hsin, Lin, Ze-Cheng, Chen, Jyun-Tu, Chang, Cheng-Chung, Wang, Gou-Jen
Format: Article
Language:English
Subjects:
Arrays
HbA1c detection
Linearity
microcone array
Nanoparticles
Photolithography
Photoresists
Raman scattering
Raman spectra
Reducing agents
Resists
Rhodamine 6G
semiconductor fabrication process
Silver
silver nanoparticles
Sodium citrate
Spinning
Stabilizers (agents)
Substrates
Surface treatment
surface-enhanced Raman scattering substrate
Thin films
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Summary:In this study, we developed a novel surface-enhanced Raman scattering (SERS) substrate formed by depositing silver nanoparticles (AgNPs) on a silver thin film-coated photoresist (PR) microcone array. The semiconductor photolithographic process was adopted for fabricating the PR microcone array. The hotspot enhancement effect of the SERS substrates was optimized by adjusting the concentration of the trisodium citrate, which was used as a reducing agent and a stabilizing agent for the synthesis of AgNPs. Experimental results showed that the proposed SERS substrate could detect the indicating peaks of Rhodamine 6G (R6G) at a relatively low concentration of 10 -12 M. A standard detection curve for HbA1c detection with a linear detection range of 5000-20000 ng/mL with a good linearity of 0.994 and a limit of detection (LOD) of 850.2 ng/mL was further established by adding HbA1c agent to artificial blood to simulate a real environmental condition. Recovery rate detection experiments confirmed the reproducibility of the established standard detection curve.
ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2023.3338640