An EEG Acquisition and Biomarker-Extraction System Using Low-Noise-Amplifier and Compressive-Sensing Circuits Based on Flexible, Thin-Film Electronics

This paper presents an electroencephalogram (EEG) acquisition and biomarker-extraction system based on flexible, thin-film electronics. There exist commercial, single-use, flexible, pre-gelled electrode arrays; however, these are fully passive, requiring cabling to transfer sensitive, low-amplitude...

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Bibliographic Details
Published in:IEEE journal of solid-state circuits 2017-01, Vol.52 (1), p.309-321
Main Authors: Moy, Tiffany, Liechao Huang, Rieutort-Louis, Warren, Can Wu, Cuff, Paul, Wagner, Sigurd, Sturm, James C., Verma, Naveen
Format: Article
Language:English
Subjects:
Algorithms
Amorphous silicon
Amorphous silicon (a-Si)
Amplifiers
Biomarkers
chopper stabilization
Circuits
compressive sensing
Electrodes
Electroencephalography
Electronics
Feature extraction
flexible electronics
Integrated circuits
Logic gates
Photovoltaic cells
Receivers & amplifiers
Reconstruction
seizure detection
Seizures
Semiconductor devices
Signal integrity
Signal processing
Thin film transistors
thin-film transistor (TFT)
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Summary:This paper presents an electroencephalogram (EEG) acquisition and biomarker-extraction system based on flexible, thin-film electronics. There exist commercial, single-use, flexible, pre-gelled electrode arrays; however, these are fully passive, requiring cabling to transfer sensitive, low-amplitude signals to external electronics for readout and processing. This work presents an active EEG acquisition system on flex, based on amorphous silicon (a-Si) thin-film transistors (TFTs). The system incorporates embedded chopper-stabilized a-Si TFT low-noise amplifiers, to enhance signal integrity, and a-Si TFT compressive-sensing scanning circuits, to enable reduction of EEG data from many channels onto a single interface, for subsequent processing by a CMOS IC. Further, the system uses an algorithm, by which spectral-energy features, a key EEG biomarker, are extracted directly from the compressed signals. We demonstrate a prototype, performing EEG acquisition from a human subject, and compressed EEG data. The TFT amplifier achieves a noise PSD of 230 nV/√Hz. reconstruction and seizure detection via analog replay of patient Seizure detection, at up to 64× compression, achieves error rates
ISSN:0018-9200
1558-173X
DOI:10.1109/JSSC.2016.2598295