Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress

Immunomechanobiology, the study of how physical forces influence the behavior and function of immune cells, is a rapidly growing area of research. It is becoming increasingly recognized that mechanical stimuli, such as fluid shear forces, are a critical determinant of immune cell regulation. In this...

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Bibliographic Details
Published in:IEEE reviews in biomedical engineering 2024-11, p.1-16
Main Authors: N.S., Sarna, N.M., Curry, E., Aalaei, B.G., Kaufman, M.R., King
Format: Article
Language:English
Subjects:
Adhesives
Biological Cells
Biological Interactions
Biological System Modeling
Biomedical Engineering
Blood
Cancer Treatment
Cell Signaling
Cells (biology)
Diseases
Endothelial cells
Fluid Dynamics
Fluid Flow Control
Force
Immune system
Immunology
Immunotherapy
Mechanobiology
Microfluidics
Receptor
Stress
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Summary:Immunomechanobiology, the study of how physical forces influence the behavior and function of immune cells, is a rapidly growing area of research. It is becoming increasingly recognized that mechanical stimuli, such as fluid shear forces, are a critical determinant of immune cell regulation. In this review, we discuss the principles and significance of various mechanical forces present within the human body, with a focus on fluid shear flow and its impact on immune cell activation and function. Moreover, we discuss engineering approaches used to study immune cell mechanobiology, and their implications in health and diseases such as cancer, autoimmune disorders, and infectious disease.
ISSN:1937-3333
1941-1189
DOI:10.1109/RBME.2024.3505073