Automated On-Line Determination of Membrane Responsiveness Curves

A system has been designed which provides automated on-line continuous plots of membrane responsiveness curves. The system is composed of amplifiers, positive peak-detecting and sample-and-hold circuitry, control logic, and display oscilloscopes. With an intracellular recording microelectrode impale...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1978-09, Vol.BME-25 (5), p.481-483
Main Authors: Zoble, Robert G., Selevan, James, Currie, Edward H., Lasseter, Kenneth C.
Format: Article
Language:English
Subjects:
Automatic control
Automation
Biomembranes
Control systems
Delay
Displays
Kinetic theory
Logic circuits
Membrane Potentials - drug effects
Microelectrodes
Oscilloscopes
Preamplifiers
Reaction Time
Sodium - pharmacology
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Summary:A system has been designed which provides automated on-line continuous plots of membrane responsiveness curves. The system is composed of amplifiers, positive peak-detecting and sample-and-hold circuitry, control logic, and display oscilloscopes. With an intracellular recording microelectrode impaled in a cardiac Purkinje fiber, the system acquires the membrane potential and maximum upstroke velocity of an action potential elicited from the resting or take-off potential. The resulting X-Y plot of varying membrane take-off potentials versus maximum upstroke velocity gives the "membrane responsiveness" relationship. This relationship reflects the relative availability of the depolarizing sodium system at different membrane potentials.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.1978.326357