Assessment of Biocompatibility of Chronically Implanted Polyimide and Platinum Intrafascicular Electrodes

Longitudinal intrafascicular electrodes (LIFEs) are electrodes designed to be placed inside the peripheral nerve to improve stimulation selectivity and to increase the recording signal-to-noise ratio. We evaluated the functional and morphological effects of either Pt wire LIFEs or polyimide-based th...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2007-02, Vol.54 (2), p.281-290
Main Authors: Lago, Natalia, Yoshida, Ken, Koch, Klaus P., Navarro, Xavier
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Biocompatible Materials - adverse effects
Biocompatible Materials - chemistry
Biological cells
Electrodes
Electrodes, Implanted - adverse effects
Equipment Design
Equipment Failure Analysis
Fasciotomy
Foreign-Body Reaction - etiology
Foreign-Body Reaction - pathology
Interface
intrafascicular electrode
Neural prosthesis
Neuritis - etiology
Neuritis - pathology
neuroprosthesis
peripheral nerve
Physiology
Platinum
Platinum - adverse effects
polyimide
Polyimides
Polymers
Rats
Rats, Sprague-Dawley
Resins, Synthetic - adverse effects
Sciatic Nerve - physiology
Testing
Transistors
Wire
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Summary:Longitudinal intrafascicular electrodes (LIFEs) are electrodes designed to be placed inside the peripheral nerve to improve stimulation selectivity and to increase the recording signal-to-noise ratio. We evaluated the functional and morphological effects of either Pt wire LIFEs or polyimide-based thin-film LIFEs implanted in the rat sciatic nerve for 3 mo. The newly designed thin-film LIFEs are more flexible, can be micromachined and allow placement of more active electrode sites than conventional Pt LIFEs. Functional results at 1 mo indicated an initial decline in the nerve conduction velocity and in the amplitude of muscle responses, which recovered during the following 2 mo towards normal values. Morphological results showed that both types of LIFEs induced a mild scar response and a focal but chronic inflammatory reaction, which were limited to a small area around the electrode placed in the nerve. Both types of LIFEs can be considered biocompatible and cause reversible, minimal nerve damage
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2006.886617