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Towards BirthAlert-A Clinical Device Intended for Early Preterm Birth Detection
Preterm birth causes 1 million infant deaths worldwide every year, making it the leading cause of infant mortality. Existing diagnostic tests such as transvaginal ultrasound or fetal fibronectin either cannot determine if preterm birth will occur in the future or can only predict the occurrence once...
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| Published in: | IEEE transactions on biomedical engineering 2013-12, Vol.60 (12), p.3484-3493 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| container_issue | 12 |
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| container_title | IEEE transactions on biomedical engineering |
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| creator | Etemadi, Mozziyar Chung, Philip Heller, J. Alex Liu, Jonathan A. Rand, Larry Roy, Shuvo |
| description | Preterm birth causes 1 million infant deaths worldwide every year, making it the leading cause of infant mortality. Existing diagnostic tests such as transvaginal ultrasound or fetal fibronectin either cannot determine if preterm birth will occur in the future or can only predict the occurrence once cervical shortening has begun, at which point it is too late to reverse the accelerated parturition process. Using iterative and rapid prototyping techniques, we have developed an intravaginal proof-of-concept device that measures both cervical bioimpedance and cervical fluorescence to characterize microstructural changes in a pregnant woman's cervix in hopes of detecting preterm birth before macroscopic changes manifest in the tissue. If successful, such an early alert during this "silent phase" of the preterm birth syndrome may open a new window of opportunity for interventions that may reverse and avoid preterm birth altogether. |
| doi_str_mv | 10.1109/TBME.2013.2272601 |
| format | article |
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Alex ; Liu, Jonathan A. ; Rand, Larry ; Roy, Shuvo</creator><creatorcontrib>Etemadi, Mozziyar ; Chung, Philip ; Heller, J. Alex ; Liu, Jonathan A. ; Rand, Larry ; Roy, Shuvo</creatorcontrib><description>Preterm birth causes 1 million infant deaths worldwide every year, making it the leading cause of infant mortality. Existing diagnostic tests such as transvaginal ultrasound or fetal fibronectin either cannot determine if preterm birth will occur in the future or can only predict the occurrence once cervical shortening has begun, at which point it is too late to reverse the accelerated parturition process. Using iterative and rapid prototyping techniques, we have developed an intravaginal proof-of-concept device that measures both cervical bioimpedance and cervical fluorescence to characterize microstructural changes in a pregnant woman's cervix in hopes of detecting preterm birth before macroscopic changes manifest in the tissue. 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(IEEE) Dec 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-b2ba2b4212dc0914e81b18d160c9f632109f7d500f856207ea4ef66919407b9b3</citedby><cites>FETCH-LOGICAL-c447t-b2ba2b4212dc0914e81b18d160c9f632109f7d500f856207ea4ef66919407b9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/6566052$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,54555,54796,54932</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/6566052$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23893706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Etemadi, Mozziyar</creatorcontrib><creatorcontrib>Chung, Philip</creatorcontrib><creatorcontrib>Heller, J. Alex</creatorcontrib><creatorcontrib>Liu, Jonathan A.</creatorcontrib><creatorcontrib>Rand, Larry</creatorcontrib><creatorcontrib>Roy, Shuvo</creatorcontrib><title>Towards BirthAlert-A Clinical Device Intended for Early Preterm Birth Detection</title><title>IEEE transactions on biomedical engineering</title><addtitle>TBME</addtitle><addtitle>IEEE Trans Biomed Eng</addtitle><description>Preterm birth causes 1 million infant deaths worldwide every year, making it the leading cause of infant mortality. Existing diagnostic tests such as transvaginal ultrasound or fetal fibronectin either cannot determine if preterm birth will occur in the future or can only predict the occurrence once cervical shortening has begun, at which point it is too late to reverse the accelerated parturition process. Using iterative and rapid prototyping techniques, we have developed an intravaginal proof-of-concept device that measures both cervical bioimpedance and cervical fluorescence to characterize microstructural changes in a pregnant woman's cervix in hopes of detecting preterm birth before macroscopic changes manifest in the tissue. If successful, such an early alert during this "silent phase" of the preterm birth syndrome may open a new window of opportunity for interventions that may reverse and avoid preterm birth altogether.</description><subject>Bioimpedance</subject><subject>Biomedical measurement</subject><subject>bluetooth</subject><subject>Cervical Ripening - physiology</subject><subject>Cervix Uteri - physiology</subject><subject>Early Diagnosis</subject><subject>Electric Impedance</subject><subject>Electrodes</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Impedance</subject><subject>Impedance measurement</subject><subject>Infant mortality</subject><subject>Obstetrics</subject><subject>Optical Imaging - methods</subject><subject>physiologic sensing</subject><subject>Pregnancy</subject><subject>Premature birth</subject><subject>Premature Birth - diagnosis</subject><subject>Probes</subject><subject>sensors</subject><subject>Softening</subject><subject>spectroscopy</subject><subject>Spectrum Analysis</subject><issn>0018-9294</issn><issn>1558-2531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpdkVFr2zAUhcVYWdK0P2AMhqEvfXGqK8uy9TJIs2wNtLQP6bOQ5etVwbE6Senov69CsrD1SYj7naN7dAj5DHQKQOXV6vpuMWUUiiljFRMUPpAxlGWds7KAj2RMKdS5ZJKPyGkI63TlNRefyIgVtSwqKsbkfuX-aN-G7Nr6-DTr0cd8ls17O1ij--w7vliD2XKIOLTYZp3z2UL7_jV78BjRb_a6xEU00brhjJx0ug94fjgn5PHHYjW_yW_vfy7ns9vccF7FvGGNZg1nwFpDJXCsoYG6BUGN7ETBUrquaktKu7oUjFaoOXZCSJCcVo1sign5tvd93jYbbA0O0etePXu70f5VOW3V_5PBPqlf7kVxQcv0bjK4PBh493uLIaqNDQb7Xg_otkFBRXnBZfrIhF68Q9du64cUT0Gy42k_USYK9pTxLgSP3XEZoGpXl9rVpXZ1qUNdSfP13xRHxd9-EvBlD1hEPI5FKVIKVrwBkLyX1w</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Etemadi, Mozziyar</creator><creator>Chung, Philip</creator><creator>Heller, J. 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| ispartof | IEEE transactions on biomedical engineering, 2013-12, Vol.60 (12), p.3484-3493 |
| issn | 0018-9294 1558-2531 |
| language | eng |
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| source | IEEE Xplore All Conference Series |
| subjects | Bioimpedance Biomedical measurement bluetooth Cervical Ripening - physiology Cervix Uteri - physiology Early Diagnosis Electric Impedance Electrodes Female Fluorescence Humans Impedance Impedance measurement Infant mortality Obstetrics Optical Imaging - methods physiologic sensing Pregnancy Premature birth Premature Birth - diagnosis Probes sensors Softening spectroscopy Spectrum Analysis |
| title | Towards BirthAlert-A Clinical Device Intended for Early Preterm Birth Detection |
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