Sensing Inhalation Injury-Associated Changes in Airway Wall Compliance by Anatomic Optical Coherence Elastography

Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2021-08, Vol.68 (8), p.2360-2367
Main Authors: Bu, Ruofei, Balakrishnan, Santosh, Iftimia, Nicusor, Price, Hillel, Zdanski, Carlton, Mitran, Sorin, Oldenburg, Amy L.
Format: Article
Language:English
Subjects:
Animals
Biomedical engineering
biomedical imaging
Burns
Catheters
Coherence
Compliance
Elasticity Imaging Techniques
Elastography
Electron tubes
Heterogeneity
Imaging
Inhalation
Injuries
Lung Diseases
optical coherence tomography
optical imaging
Phantoms
Respiration
Respiratory tract
Steam
Strain
Swine
Tomography, Optical Coherence
Trachea
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Summary:Quantitative methods for assessing the severity of inhalation (burn) injury are needed to aid in treatment decisions. We hypothesize that it is possible to assess the severity of injuries on the basis of differences in the compliance of the airway wall. Here, we demonstrate the use of a custom-built, endoscopic, anatomic optical coherence elastography (aOCE) system to measure airway wall compliance. The method was first validated using airway phantoms, then performed on ex vivo porcine tracheas under varying degrees of inhalation (steam) injury. A negative correlation between aOCE-derived compliance and severity of steam injuries is found, and spatially-resolved compliance maps reveal regional heterogeneity in airway properties.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2020.3037288