Biosensor Chip for Point-of-Care Diagnostics: Carbon Nanotube Sensing Platform for Bacterial Detection and Identification

Emerging technologies, such as carbon nanotubes (CNTs), show exciting benefits for next-generation electronic systems and have recently been incorporated within commercial fabrication facilities and foundries. Here we demonstrate a real-world application of carbon nanotube field-effect transistors (...

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Bibliographic Details
Published in:IEEE transactions on nanotechnology 2024, Vol.23, p.281-285
Main Authors: Ho, Rebecca, Fuller, Samuel, Lee, Hae-Seung, Shulaker, Max M.
Format: Article
Language:English
Subjects:
Antibodies
Biological properties
Biosensor
Biosensors
Carbon nanotubes
CNFETs
CNTFETs
diagnostics
Electronic systems
Fabrication
Field effect transistors
Foundries
Multiplexing
New technology
Pathogens
Semiconductor device measurement
Semiconductor devices
Sensors
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Summary:Emerging technologies, such as carbon nanotubes (CNTs), show exciting benefits for next-generation electronic systems and have recently been incorporated within commercial fabrication facilities and foundries. Here we demonstrate a real-world application of carbon nanotube field-effect transistors (CNFETs) leveraging these foundry capabilities: performing disease diagnostics by detecting and identifying infectious pathogens in model biological samples. This Biosensor chip leverages the benefits of 200 mm wafer-scale and VLSI-compatible foundry fabrication of CNFETs, which can be seamlessly integrated with the mature sensing modality of antibody-based targeted antigen binding, to realize a robust and manufacturable biosensor technology. As a demonstration, we realize Biosensor chips that are capable of detecting and identifying three different infectious pathogens simultaneously through multiplexing across hundreds of functionalized CNFET-antibody biosensors within each chip.
ISSN:1536-125X
1941-0085
DOI:10.1109/TNANO.2024.3380997