Design and Simulation of Proportional Biological Operational Mu-Circuit

It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device-Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The resu...

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Bibliographic Details
Published in:IEEE transactions on nanobioscience 2015-03, Vol.14 (2), p.248-253
Main Authors: Xu, Dechang, Cai, Zhipeng, Liu, Ke, Zeng, Xiangmiao, Ouyang, Yujing, Dai, Cuihong, Hou, Aiju, Cheng, Dayou, Li, Jianzhong
Format: Magazinearticle
Language:English
Subjects:
Algorithms
Animals
Biological system modeling
Computer Simulation
Feedback, Physiological - physiology
Gene Regulatory Networks - genetics
Humans
Integrated circuit modeling
Logic gates
Logistic Models
Mathematical model
Modeling
Models, Genetic
Nanobioscience
Promoter Regions, Genetic - genetics
proportional regulation
Proteins
Signal Transduction - genetics
Simulation
Transcription, Genetic - genetics
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Summary:It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device-Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2015.2403871