Enhanced Osteogenesis of Human Mesenchymal Stem Cells in Presence of Single-Walled Carbon Nanotubes

Human mesenchymal stem cells (hMSCs) have attracted significant attention for tissue engineering because of their ability to differentiate into bone cells, chondrocytes, adipocytes, and muscle cells. Single-walled carbon nanotubes (SWCNTs) have been considered as a potential material for tissue engi...

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Bibliographic Details
Published in:IEEE transactions on nanobioscience 2019-07, Vol.18 (3), p.463-468
Main Authors: Kim, Hye-Been, Jin, Bin, Patel, Dinesh K., Kim, Jin-Woo, Kim, Jangho, Seonwoo, Hoon, Lim, Ki-Taek
Format: Magazinearticle
Language:English
Subjects:
Adipocytes
and osteogenesis
Biocompatibility
Biocompatible Materials - chemistry
Biomaterials
Biomedical materials
Carbon nanotubes
Cell Culture Techniques - methods
Cell Survival - drug effects
Cells (biology)
Cells, Cultured
Chondrocytes
Cytotoxicity
Differentiation (biology)
Electrostatics
Gene expression
High aspect ratio
Human mesenchymal stem cells
Humans
Mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - drug effects
Mesenchyme
Muscles
Nanobioscience
Nanotechnology
Nanotubes
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - toxicity
Osteogenesis
Osteogenesis - drug effects
Single wall carbon nanotubes
single-walled carbon nanotubes
Sonication
Stem cells
Tissue engineering
Toxicity
Viability
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Summary:Human mesenchymal stem cells (hMSCs) have attracted significant attention for tissue engineering because of their ability to differentiate into bone cells, chondrocytes, adipocytes, and muscle cells. Single-walled carbon nanotubes (SWCNTs) have been considered as a potential material for tissue engineering applications due to their unique properties, such as high aspect ratio, excellent electrocatalytic activity, and biocompatibility. Here we prepared exfoliated SWCNTs layers through an ultra-sonication process in the acidic medium and evaluated their cytotoxicity using hMSCs. Improved viability and osteogenesis of hMSCs were observed in the presence of exfoliated SWCNTs. Besides, the higher expression of osteogenic differentiation-related genes in the presence of exfoliated SWCNTs further confirmed their enhanced osteogenic nature. These results indicated the potential of SWCNTs as a biomaterial for tissue engineering applications.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2019.2914127