MRI Investigation of the Linkage Between Respiratory Motion of the Heart and Markers on Patient's Abdomen and Chest: Implications for Respiratory Amplitude Binning List-Mode PET and SPECT Studies

• Published in: IEEE transactions on nuclear science 2014-02, Vol.61 (1), p.192-201
• Main Authors: Dasari, Paul, Johnson, Karen, Dey, Joyoni, Lindsay, Clifford, Shazeeb, Mohammed S., Mukherjee, Joyeeta Mitra, Shaokuan Zheng, King, Michael A.
• Format: Article
• Language: English
• Subjects: Abdomen; Amplitudes; Cardiac respiratory motion; Chest; Correlation; Correlation analysis; emission tomography; Estimating; Heart; Hysteresis; Magnetic resonance imaging; Markers; MRI; Navigation; signal processing; Silicon; Tracking; Volunteers
• ISSN: 0018-9499; 1558-1578
• DOI: 10.1109/TNS.2013.2294829

Respiratory motion of the heart impacts the diagnostic accuracy of myocardial-perfusion emission-imaging studies. Amplitude binning has come to be the method of choice for binning list-mode based acquisitions for correction of respiratory motion in PET and SPECT. In some subjects respiratory motion exhibits hysteretic behavior similar to damped non-linear cyclic systems. The detection and correction of hysteresis between the signals from surface movement of the patient's body used in binning and the motion of the heart within the chest remains an open area for investigation. This study reports our investigation in nine volunteers of the combined MRI tracking of the internal respiratory motion of the heart using Navigators with stereo-tracking of markers on the volunteer's chest and abdomen by a visual-tracking system (VTS). The respiratory motion signals from the internal organs and the external markers were evaluated for hysteretic behavior analyzing the temporal correspondence of the signals. In general, a strong, positive correlation between the external marker motion (AP direction) and the internal heart motion (SI direction) during respiration was observed. The average ± standard deviation in the Spearman's ranked correlation coefficient (ρ) over the nine volunteer studied was 0.92±0.1 between the external abdomen marker and the internal heart, and 0.87±0.2 between the external chest marker and the internal heart. However despite the good correlation on average for the nine volunteers, in three studies a poor correlation was observed due to hysteretic behavior between inspiration and expiration for either the chest marker and the internal motion of the heart, or the abdominal marker and the motion of the heart. In all cases we observed a good correlation of at least either the abdomen or the chest with the heart. Based on this result, we propose the use of marker motion from both the chest and abdomen regions when estimating the internal heart motion to detect and address hysteresis when binning list-mode emission data.