Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in M alaysia

• Published in: Journal of dermatology 2013-11, Vol.40 (11), p.874-880
• Main Authors: Wong, Su‐ming, Ng, Ting Guan, Baba, Roshidah
• Format: Article
• Language: English
• ISSN: 0385-2407; 1346-8138
• DOI: 10.1111/1346-8138.12265

Staphylococcus aureus is frequently found in patients with atopic dermatitis ( AD ) and contributes to disease exacerbation. The objective of this study was to evaluate the efficacy and safety of bleach baths as an adjunctive treatment in AD patients. Patients between 2 and 30 years old with moderate to severe AD were enrolled in a prospective, randomized, placebo‐controlled study. Patients soaked in diluted bleach or distilled water baths for 10 min, twice a week for 2 months. Efficacy assessments included the E czema A rea and S everity I ndex ( EASI ) scores and S . aureus density was determined using quantitative bacterial cultures. Patients in the treatment group showed significant reductions in EASI scores. A 41.9% reduction in S . aureus density from baseline was seen at 1 month further reducing to 53.3% at 2 months. Equal numbers of patients in both groups experienced mild side‐effects. This study demonstrates that diluted bleach baths clinically improved AD in as little as 1 month. No patient withdrew from the treatment arm because of intolerance to the baths.