Coexistence of MACC 1 and NM 23‐H1 dysregulation and tumor budding promise early prognostic evidence for recurrence risk of early‐stage colon cancer

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2018-02, Vol.126 (2), p.99-108
• Main Authors: Ozturk, Ersin, Aksoy, Secil AK, Ugras, Nesrin, Tunca, Berrin, Ceylan, Serkan, Tezcan, Gulcin, Yilmazlar, Tuncay, Yerci, Omer, Egeli, Unal, Cecener, Gulsah
• Format: Article
• Language: English
• ISSN: 0903-4641; 1600-0463
• DOI: 10.1111/apm.12801

The tumor‐node‐metastasis ( TNM ) classification, the presence of a mucinous component, and signet ring cells are well‐known criteria for identifying patients at a high risk for recurrence and determining the therapeutic approach for early‐stage colon cancer ( eCC ). Nevertheless, recurrence can unexpectedly occur in some eCC cases after surgical resection. The aims of the present study were to evaluate the relation of dysregulated MACC 1, c‐ MET , and NM 23‐H1 expression with the histopathological features of tumors in recurrence formation in eCC cases. A total of 100 sporadic eCC patients without poor prognosis factors were evaluated in this study. The relationship between the altered expression of MACC 1 , c‐ MET , and NM 23‐H1 and pathological microenvironmental features, including the presence of tumor budding and desmoplasia, were assessed. The primary outcomes, including 5‐year overall survival ( OS ) and disease‐free survival ( DFS ), were also measured. Compared with nonrecurrent patients, the expression level of MACC 1 was 8.27‐fold higher, and NM 23‐H1 was 11.36‐fold lower in patients with recurrence during the 5‐year follow‐up (p = 0.0345 and p = 0.0301, respectively). In addition, the coexistence of high MACC 1 and low NM 23‐H1 expression and tumor budding was associated with short OS (p