Comparison of the EXtracorporeal TReatments In Poisoning (EXTRIP) and Paris criteria for neurotoxicity in lithium poisoned patients

Aims Two guidelines for haemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single centre retrospective one (Paris) differ. We compared outcomes in lithium poisoning based on these criteria with a primary outcome of worsening neurological...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2021-10, Vol.87 (10), p.3871-3877
Main Authors: DiSalvo, Philip C., Furlano, Emma, Su, Mark K., Gosselin, Sophie, Hoffman, Robert S.
Format: Article
Language:English
Subjects:
Drug Overdose
extracorporeal treatment
haemodialysis
Humans
Lithium
Paris
poisoning
Poisons
Retrospective Studies
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Summary:Aims Two guidelines for haemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single centre retrospective one (Paris) differ. We compared outcomes in lithium poisoning based on these criteria with a primary outcome of worsening neurological symptoms in patients for whom EXTRIP and Paris criteria were discordant. Methods Poison centre data were queried for lithium poisoned patients for whom haemodialysis was either recommended or performed. Patients were categorized according to EXTRIP and Paris criteria and excluded if the peak lithium concentration was
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.14802