Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non‐ H odgkin lymphoma subtypes

A recent meta‐analysis of three genome‐wide association studies of chronic lymphocytic leukaemia ( CLL ) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non‐ H odgkin lymphoma ( NHL ) su...

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Published in:British journal of haematology 2012-12, Vol.159 (5), p.572-576
Main Authors: Slager, Susan L., Camp, Nicola J., Conde, Lucia, Shanafelt, Tait D., Achenbach, Sara J., Rabe, Kari G., Kay, Neil E., Novak, Anne J., Call, Timothy G., Bracci, Paige M., Sille, Fenna M. C., Sanchez, Sylvia, Akers, Nicholas K., Cunningham, Julie M., Serie, Daniel J., McDonnell, Shannon K., Leis, Jose F., Wang, Alice H., Weinberg, J. Brice, Glenn, Martha, Link, Brian, Vachon, Celine M., Lanasa, Mark C., Skibola, Christine F., Cerhan, James R.
Format: Article
Language:English
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Summary:A recent meta‐analysis of three genome‐wide association studies of chronic lymphocytic leukaemia ( CLL ) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non‐ H odgkin lymphoma ( NHL ) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P  =   0·01; rs210142: P  =   6·8 × 10 −3 ). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12070