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Prognostic roles of absolute monocyte and absolute lymphocyte counts in patients with advanced‐stage follicular lymphoma in the rituximab era: an analysis from the FOLL 05 trial of the Fondazione Italiana Linfomi
Recently, in an attempt to improve the discrimination power of the international prognostic index ( IPI ), patients with diffuse large B‐cell lymphoma were evaluated to determine the prognostic roles of peripheral blood absolute monocyte count ( AMC ) and absolute lymphocyte count ( ALC ). Here, we...
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Published in: | British journal of haematology 2015-05, Vol.169 (4), p.544-551 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Recently, in an attempt to improve the discrimination power of the international prognostic index (
IPI
), patients with diffuse large B‐cell lymphoma were evaluated to determine the prognostic roles of peripheral blood absolute monocyte count (
AMC
) and absolute lymphocyte count (
ALC
). Here, we analysed data of 428 patients with follicular lymphoma (
FL
) enrolled in a prospective, randomized trial (
FOLL
05 study) conducted by Fondazione Italiana Linfomi, to assess the impact of
AMC
and
ALC
on progression‐free survival (
PFS
). All patients had been treated with one of three treatment combinations: (i) rituximab (R) plus cyclophosphamide, vincristine and prednisone; (ii) R plus cyclophosphamide, doxorubicin, vincristine and prednisone or (iii) R plus mitoxantrone and fludarabine. We showed that only
AMC
was a powerful predictor of
PFS
, and possibly overall survival, in patients with
FL
treated with combination chemotherapy regimens that contained R. The
AMC
can be used alone as a novel, simple factor that can predict survival outcome in patients with
FL
, independent of the immunochemotherapy regimen. It may therefore be widely used by clinicians, due to its simplicity and broad applicability. Additionally, it can be combined with other factors that determine the
IPI
or
FLIPI
, to increase the discriminating ability of these indices. |
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ISSN: | 0007-1048 1365-2141 |
DOI: | 10.1111/bjh.13332 |