Expression and roles of W ilms' tumor 1‐associating protein in glioblastoma

Glioblastoma is a diffusely growing malignant brain tumor and among the most aggressive of all tumors. Wilms' tumor 1‐associating protein ( WTAP ) is a nuclear protein that has been associated with regulation of proliferation and apoptosis. Although its dynamic expression and physiological func...

Full description

Saved in:
Bibliographic Details
Published in:Cancer science 2012-12, Vol.103 (12), p.2102-2109
Main Authors: Jin, Du‐Il, Lee, Sang Weon, Han, Myoung‐Eun, Kim, Hyun‐Jung, Seo, Seon‐Ae, Hur, Gi‐Yeong, Jung, Shin, Kim, Bong‐Seon, Oh, Sae‐Ock
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioblastoma is a diffusely growing malignant brain tumor and among the most aggressive of all tumors. Wilms' tumor 1‐associating protein ( WTAP ) is a nuclear protein that has been associated with regulation of proliferation and apoptosis. Although its dynamic expression and physiological functions in vascular cells have been reported, those in other cells are largely unknown. Here, we show for the first time that WTAP is overexpressed in glioblastoma. Moreover we found that WTAP regulates migration and invasion of glioblatoma cells. Specific knockdown by si RNA or overexpression by c DNA regulated migration and invasion of cancer cells. In xenograft study, WTAP overexpression made cancer cells more tumorigenic. In the investigation for its underlying mechanism, we found that the activity of epidermal growth factor receptor can be regulated by WTAP . These results reveal a novel function of WTAP and suggest its clinical application.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12022