LncRNA SNHG15: A potential therapeutic target in the treatment of colorectal cancer

• Published in: Chemical biology & drug design 2023-05, Vol.101 (5), p.1138-1150
• Main Authors: Olatubosun, Mutolib Olabayo, Abubakar, Murtala Bello, Batiha, Gaber El‐Saber, Malami, Ibrahim, Ibrahim, Kasimu Ghandi, Abubakar, Bilyaminu, Bello, Muhammad Bashir, Alexiou, Athanasios, Imam, Mustapha Umar
• Format: Article
• Language: English
• Subjects: Cell Line, Tumor; Cell Proliferation - genetics; colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Gene Expression Regulation, Neoplastic; Humans; lncRNA; MicroRNAs - genetics; micro‐RNAs; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; SNHG15; Wnt/β‐catenin
• ISSN: 1747-0277; 1747-0285
• DOI: 10.1111/cbdd.14036

The global burden of colorectal cancer (CRC) is increasing annually. CRC could develop from genetic and phenotypic factors involving changes in gene expression. Incredibly, the human genome transcribes into non‐coding RNAs, among which long non‐coding RNAs (lncRNAs) signify the most crucial part of the transcriptome in multicellular organisms. lncRNAs affect gene expression at multiple levels, from transcription to protein localization and stability. Recent studies have implicated lncRNA small nucleolar RNA host gene 15 (SNHG15) in cancers occurrence and progression. Previously, an indication suggests SNHG15 overexpression triggers proliferation, metastasis, and impedes apoptosis in CRC. Further, through its activity of binding micro‐RNAs, lncRNA SNHG15 modulates genes associated with CRC progression and promotes CRC resistance to chemotherapeutic drugs. Here, we reviewed recent findings on the various mechanisms and roles of lncRNA SNHG15 implicated in CRC tumorigenesis. We further highlight how SNHG15 plays a vital role in regulating critical pathways linked to the development and progression of CRC. Finally, we highlight how SNHG15 can be modulated for CRC treatments and the various therapeutic strategies to be implored when targeting SNHG15 in the context of CRC treatments. Findings from these studies present SNHG15 as a potential therapeutic target for preventing and treating CRC. This paper reviews the role of lncRNA small nucleolar RNA host gene 15 (SNHG15) in cancers’ occurrence and progression. Overexpression of SNHG15 is associated with poor survival in many human malignancies, including breast cancer, CRC, GC, glioma, hepatocellular cancer, lung cancer, and osteosarcoma, ovarian cancer, pancreatic cancer, renal cell, and thyroid cancer.