Early changes in IL‐21, IL‐22, CCL2, and CCL4 serum cytokines after outpatient autologous transplantation for multiple sclerosis: A proof of concept study

Changes in serum cytokines after autologous hematopoietic stem cell transplantation (AHSCT) in multiple sclerosis (MS) patients were documented. Thirty‐six consecutive MS patients who had their Expanded Disability Status Scale (EDSS) scored before AHSCT were prospectively enrolled. Cyclophosphamide...

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Bibliographic Details
Published in:Clinical transplantation 2020-12, Vol.34 (12), p.e14114-n/a
Main Authors: Jaime‐Pérez, José C., Turrubiates‐Hernández, Grecia A., López‐Silva, Leslie J., Salazar‐Riojas, Rosario, Gómez‐Almaguer, David
Format: Article
Language:English
Subjects:
autologous transplantation
CCL2
CCL4
Chemokine CCL2
Cytokines
Female
Hematopoietic Stem Cell Transplantation
Humans
IL‐21
IL‐22
Interleukin-22
Interleukins
Male
Middle Aged
Multiple Sclerosis
outpatient transplant
Outpatients
Proof of Concept Study
reduced‐intensity conditioning
stem cell transplantation
Transplantation Conditioning
Transplantation, Autologous
Treatment Outcome
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Summary:Changes in serum cytokines after autologous hematopoietic stem cell transplantation (AHSCT) in multiple sclerosis (MS) patients were documented. Thirty‐six consecutive MS patients who had their Expanded Disability Status Scale (EDSS) scored before AHSCT were prospectively enrolled. Cyclophosphamide (Cy) was infused at 200 mg/kg in two administrations given 10 days apart: the first dose for mobilization, the second as the conditioning regimen. Patients were mobilized with 10 µg/kg/day subcutaneous G‐CSF. Serum was collected 14 days before and 14 after AHSCT. IL‐6, IL‐9, IL‐10, IL 17‐A, IL‐21, IL‐22, IL‐23, TNF‐A, CCL2, CCL3, and CCL4 were measured by magnetic bead‐based immunoassay. t Test and Wilcoxon test were used to compare cytokine levels before and after AHSCT. There were 28 women and 8 men with a median age of 46 (15–62) years, median duration of MS was 9.5 (1–32) years, and EDSS score was 5.7 (1.5–8.0). Patients had a decrement of pro‐inflammatory IL‐21 and IL‐22 (p = .003 and p = .028) and an increment of anti‐inflammatory CCL2 and CCL4 (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14114