Associations between HbA 1c and continuous glucose monitoring-derived glycaemic variables

To identify clinically useful associations between HbA levels and various continuous glucose monitoring-derived metrics. We retrospectively analysed end-of-study HbA levels and >2 weeks of continuous glucose monitoring data collected from 530 adults with Type 1 diabetes or insulin-requiring Type...

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Bibliographic Details
Published in:Diabetic medicine 2019-12, Vol.36 (12), p.1637-1642
Main Authors: Hirsch, I B, Welsh, J B, Calhoun, P, Puhr, S, Walker, T C, Price, D A
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Blood Glucose Self-Monitoring - methods
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Glycated Hemoglobin A - analysis
Humans
Hypoglycemia - diagnosis
Hypoglycemia - epidemiology
Hypoglycemia - prevention & control
Middle Aged
Retrospective Studies
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Summary:To identify clinically useful associations between HbA levels and various continuous glucose monitoring-derived metrics. We retrospectively analysed end-of-study HbA levels and >2 weeks of continuous glucose monitoring data collected from 530 adults with Type 1 diabetes or insulin-requiring Type 2 diabetes during four randomized trials. Each trial lasted ≥24 weeks and provided central laboratory end-of-study HbA levels and continuous glucose monitoring data from the preceding 3 months. Participants were assigned to groups based on either HbA levels or continuous glucose monitoring-derived glucose values. HbA was strongly correlated with mean glucose value (r=0.80), time spent with glucose values in the 3.9-10.0 mmol/l range (time in range; r=-0.75) and percentage of glucose values >13.9 mmol/l (r=0.72), but was weakly correlated with the percentage of glucose values
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.14065